The PASTA server for protein aggregation prediction
نویسندگان
چکیده
منابع مشابه
PASTA 2.0: an improved server for protein aggregation prediction
The formation of amyloid aggregates upon protein misfolding is related to several devastating degenerative diseases. The propensities of different protein sequences to aggregate into amyloids, how they are enhanced by pathogenic mutations, the presence of aggregation hot spots stabilizing pathological interactions, the establishing of cross-amyloid interactions between co-aggregating proteins, ...
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Protein aggregation underlies an increasing number of disorders and constitutes a major bottleneck in the development of therapeutic proteins. Our present understanding on the molecular determinants of protein aggregation has crystalized in a series of predictive algorithms to identify aggregation-prone sites. A majority of these methods rely only on sequence. Therefore, they find difficulties ...
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ژورنال
عنوان ژورنال: Protein Engineering Design and Selection
سال: 2007
ISSN: 1741-0126,1741-0134
DOI: 10.1093/protein/gzm042